This is the best set of strings I've used for hybrid playing/interchanging rhythm guitar and lead guitar, playing softer parts, screaming leads or chugging lows.
In my opinion, the thicker strings are also easier on people who fret a bit harder. I'm primarily a bass player, but I also play guitar so I have a tendency to over-bend strings that are thin, these provide enough tension for me to not do that too much, which is a bonus.
Also allows for drop-tunings to some degree which I often also do. I've dropped down to A without problems but I would not go lower than that on these strings. The 52 is thick, but not THAT thick. :)
The quality is also something I've come to really count on, there have been no kinks, twists, loose winding or discoloring on the strings out-of-the-box so far. Top stuff!
But as with any string, their brilliance fades rather soon with intense playing. Pick up a few packs and you'll be set for a while. :)