I have been using these strings for my primary 24 3/4 scale guitar for some time now. I play in E Standard, and i really like the thickness these give and drop D rattle is non-existent. And if you need to, they are just thick enough for drop C, but a little rattle can occour.
I have been playing live and rehearsing with them, and they last long.
Some worry that 11-48 will be tough on your fingers and too hard to play. At first, especially the thicker G-H and E string can feel tougher to bend, but you will develop that strength in a week or 2. You get stronger and you get a thicker solid sound. I have always been pleased with Ernie Ball, and this is no exception!